GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10935120 | 1 | rs4367113 | chr3:134287975 | CEP63 | chr3:134204575-134293852:+ | 0.31 | 6.72 | 5.18E-11 | Height |
| THCA | cis | rs1076160 | 1 | rs4367688 | chr9:135791103 | C9orf98 | chr9:135600965-135754198:- | 0.23 | 5.77 | 1.44E-8 | Psoriasis |
| THCA | cis | rs10935120 | 1 | rs4368544 | chr3:134300014 | ANAPC13 | chr3:134196547-134204865:- | -0.39 | -12.22 | 4.44E-30 | Height |
| THCA | cis | rs10935120 | 1 | rs4368544 | chr3:134300014 | CEP63 | chr3:134204575-134293852:+ | -0.31 | -6.59 | 1.13E-10 | Height |
| THCA | cis | rs726288 | 1 | rs4369337 | chr10:81733742 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs9790314 | 1 | rs4370045 | chr3:160943865 | NMD3 | chr3:160939099-160971319:+ | -0.12 | -3.76 | 0.000192 | Morning vs. evening chronotype |
| THCA | cis | rs4372836 | 1 | rs4372836 | chr2:28973883 | PPP1CB | chr2:28974612-29025805:+ | 0.17 | 4.16 | 3.82E-5 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs4372836 | chr2:28973883 | TRMT61B | chr2:29072690-29093175:- | -0.51 | -10.21 | 2.93E-22 | Body mass index |
| THCA | cis | rs7552404 | 1 | rs437298 | chr1:76113770 | MSH4 | chr1:76262630-76378923:+ | -0.25 | -4.24 | 2.74E-5 | Blood metabolite levels;Acylcarnitine levels |
| THCA | cis | rs76419734 | 1 | rs4373160 | chr4:106648641 | INTS12 | chr4:106603787-106629881:- | -0.62 | -5.29 | 1.83E-7 | Post bronchodilator FEV1 |
| THCA | cis | rs4374383 | 1 | rs4374383 | chr2:112770770 | MERTK | chr2:112656191-112786945:+ | -0.16 | -3.6 | 0.000355 | Hepatitis C induced liver fibrosis |
| THCA | cis | rs8072100 | 1 | rs4375701 | chr17:45712218 | TBKBP1 | chr17:45772630-45789427:+ | -0.38 | -10.63 | 7.68E-24 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| THCA | cis | rs17001654 | 1 | rs4376175 | chr4:77057905 | NUP54 | chr4:77035818-77069655:- | -0.17 | -3.7 | 0.00024 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4376778 | chr1:46288846 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.03 | 1.24E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4376778 | chr1:46288846 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.07 | 5.54E-5 | Body mass index |